A formal total synthesis of thienamycin from 4-propargyl-2-azetidinone.
نویسندگان
چکیده
منابع مشابه
A Formal Total Synthesis of (2)-Cephalotaxine
thesis of cephalotaxine (1), the major alkaloid of the Cephalotaxus species, because of its unique structural features and antileukemic activity of its ester derivatives, harringtonine (2) and homoharringtonine (3). So far, eight total syntheses of (6)-1 including ours have been reported and the synthesis of (2)-1 has recently been achieved by Mori’s and Nagasaka’s groups. As a part of our own ...
متن کاملSynthesis and Biological Significance of Some 2-Azetidinone Derivatives
A new series of N-[2-(1H-1,2,3-benzotriazol-1-yl)ethyl]-4-(substitutedphenyl)-3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-j) were synthesized. The structures of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. The compounds 4(a-j) were screened for their antibacterial, antifungal and antitubercular activities and gave ac...
متن کاملA Simple Method for the Preparation of Cis-(3-Azido-4-Styryl)-2-Azetidinone
The synthesis of the title compound is described. Deprotection of Cis(N-Trityl-3-azido-4-Styryl)-2-azetidinone to Cis-(3-azido-4-styryl)-2-azetidinone was found to be accelerated by the special salt effect under acidic condition
متن کاملOne-pot synthesis of 2-substituted indoles from 2-aminobenzyl phosphonium salts. A formal total synthesis of arcyriacyanin A.
The reaction of (2-aminobenzyl) triphenylphosphonium bromide with aromatic aldehydes or alpha,beta-unsaturated aldehydes under microwave-assisted conditions constitutes a new synthesis of 2-substituted indoles in high yields (81-97%) in a one-pot reaction. The adduct from indole-4-carboxaldehyde was an advanced intermediate in the synthesis of arcyriacyanin A.
متن کاملSynthesis of Triethyl Propargyl Ammonium Bromide from Triethyl Amine With Propargyl Bromide
The reaction between trimethylamine with propargyl bromide was studied and the structure of triethyl propargyl ammonium bromide was illustrated by 1HNMR, IR, and Mass spectra.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1986
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.34.1434